Anti-Human Tissue Transglutaminase (anti-tTG) IgA ELISA Kit

Anti-Human Tissue Transglutaminase (anti-tTG) antibodies are autoantibodies directed against tissue transglutaminase, an enzyme that modifies gluten-derived peptides in the small intestine. These antibodies are a highly sensitive and specific biomarker for celiac disease (CD), an autoimmune enteropathy triggered by gluten ingestion in genetically predisposed individuals. Anti-tTG antibodies mediate an immune response that damages the intestinal villi, leading to malabsorption, nutrient deficiencies, and gastrointestinal and extra-intestinal symptoms. Detection of anti-tTG, particularly of the IgA isotype, is central to diagnosing CD and monitoring response to a gluten-free diet.

In the clinical setting, anti-tTG IgA is the preferred serologic test for celiac disease screening and diagnosis due to its high sensitivity and specificity. It is especially useful in patients presenting with malabsorption, chronic diarrhea, anemia, or other signs of gluten intolerance. Anti-tTG testing is also helpful in monitoring adherence to a gluten-free diet, as antibody levels typically decline with effective treatment. For patients with selective IgA deficiency, anti-tTG IgG testing is recommended to avoid false-negative results.

In research, anti-tTG antibodies serve as a biomarker for studying gluten-triggered autoimmunity, intestinal inflammation, and mucosal immune responses. They are used in epidemiological studies to identify undiagnosed celiac disease, track disease prevalence, and evaluate early immune responses to gluten. Anti-tTG measurement is also valuable in clinical trials assessing novel therapies for celiac disease, including enzyme supplementation, immune modulation, or tolerance-inducing interventions, providing an objective marker of autoimmune activity and dietary compliance.

This product is manufactured in Germany by Medipan GmbH.