What is ENDOSTATIN?


Endostatin is the biologically active 20-kDa
C-terminal fragment of collagen XVIII.

Which function does it have?Endostatin is a highly potent inhibitor of
angiogenesis
: it induces microvascular endothelial cell
apoptosis and inhibits endothelial proliferation and angiogenesis.

What is the clinical relevance
of Endostatin? Remodelling of the extracellular matrix is
present in various types of renal disease e.g. in renal carcinoma and fibrosis.
Endostatin is currently being tested as an anti-angiogenic drug.

Endostatin levels
are associated with
(click here to view summary of studies):



– kidney injury in the elderly
– cardiovascular events and survival in CKD subjects
– kidney disease and mortality in patients with type 2 Diabetes
Endostatin may improve acute kidney injury risk prediction in critically
ill subjects


How can I measure
Endostatin?

Endostatin
can easily be measured with our highly specific Endostatin ELISAs

Human ENDOSTATIN ELISA

for serum, plasma & urine

sample volume: 10 µl / well

Assay Specifications

Assay Validation Data

Instructions for Use

Mouse/Rat ENDOSTATIN ELISA


for serum and plasma
sample volume: 5 µl / well

Assay Specifications

Assay Validation Data

Instruction for Use

Features and Benefits:

SUPERIOR QUALITY – kits fully
validated (internat. quality guidelines)

HIGHLY SPECIFIC KITS
– utilizing characterized antibodies

EASY
handling
all
reagents included in the kits

LOW sample volume

FAST – results in 3
hours

Get a
20% Discount on Endostatin Kits*

*Promotion is valid through June 30, 2017.